Hideaki Nagase Selected Research

Crotalus adamanteus proteinase II (adamalysin)

11/2015	Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2).
5/2012	Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Hideaki Nagase Research Topics

Disease

25	Neoplasms (Cancer) 01/2018 - 01/2002
19	Osteoarthritis 10/2017 - 01/2003
12	Neoplasm Metastasis (Metastasis) 09/2016 - 01/2002
8	Arthritis (Polyarthritis) 01/2017 - 01/2002
8	Rheumatoid Arthritis 01/2016 - 01/2003
4	Inflammation (Inflammations) 01/2019 - 05/2010
4	Bone Resorption 01/2018 - 01/2016
4	Fibrosis (Cirrhosis) 12/2016 - 01/2002
4	Atherosclerosis 12/2016 - 01/2002
4	Melanoma (Melanoma, Malignant) 12/2015 - 04/2003
2	Osteoporosis 01/2018 - 01/2016
2	Carcinoma (Carcinomatosis) 09/2016 - 06/2010
2	Prostatic Neoplasms (Prostate Cancer) 09/2016 - 01/2016
2	Pathologic Processes 08/2004 - 09/2003
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2004 - 03/2002
2	Atherosclerotic Plaque (Atheroma) 12/2003 - 05/2003
1	Neuralgia (Stump Neuralgia) 01/2022
1	Virus Diseases (Viral Diseases) 01/2019
1	Periodontitis 01/2018
1	Postmenopausal Osteoporosis 01/2018
1	Chronic Renal Insufficiency 01/2017
1	Connective Tissue Diseases (Connective Tissue Disease) 10/2016
1	Atrophy 01/2016
1	Osteolysis 01/2016
1	Experimental Melanoma 12/2015
1	Osteophyte 11/2015
1	Joint Diseases (Joint Disease) 03/2015
1	Breast Neoplasms (Breast Cancer) 02/2015
1	Colorectal Neoplasms (Colorectal Cancer) 01/2015
1	Experimental Arthritis 03/2014
1	Aneurysm (Aneurysms) 11/2013
1	Chondrosarcoma 01/2013
1	Chronic Obstructive Pulmonary Disease (COPD) 09/2012
1	Oligodendroglioma 05/2012
1	Necrosis 08/2010

Drug/Important Bio-Agent (IBA)

21	Matrix Metalloproteinases (MMPs)IBA 01/2018 - 01/2002
13	Metalloproteases (Metalloproteinases)IBA 01/2019 - 01/2003
9	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 05/2003
9	Aggrecans (Aggrecan)IBA 01/2016 - 01/2003
7	DisintegrinsIBA 02/2015 - 09/2007
6	CollagenIBA 01/2018 - 03/2002
6	ThrombospondinsIBA 11/2015 - 12/2004
6	EnzymesIBA 03/2014 - 04/2006
5	Tissue Inhibitor of Metalloproteinase-3IBA 10/2017 - 04/2003
5	Biological ProductsIBA 01/2017 - 09/2003
4	Collagenases (Collagenase)FDA Link 01/2018 - 03/2002
3	Matrix Metalloproteinase 13IBA 12/2016 - 08/2009
3	Proteoglycans (Proteoglycan)IBA 11/2015 - 10/2008
3	Proteins (Proteins, Gene)FDA Link 02/2015 - 01/2003
3	Tissue Inhibitor of Metalloproteinase-1IBA 01/2015 - 03/2002
2	Pharmaceutical PreparationsIBA 01/2022 - 03/2015
2	Estrogens (Estrogen)FDA Link 01/2018 - 01/2016
2	Dinoprostone (PGE2)FDA Link 01/2016 - 12/2015
2	ProstaglandinsIBA 01/2016 - 12/2015
2	Crotalus adamanteus proteinase II (adamalysin)IBA 11/2015 - 05/2012
2	CytokinesIBA 07/2015 - 05/2010
2	Matrix Metalloproteinase InhibitorsIBA 03/2014 - 01/2006
2	ZymosanIBA 03/2014 - 02/2011
2	aggrecanaseIBA 04/2013 - 05/2012
2	CathepsinsIBA 02/2011 - 05/2010
2	Cysteine (L-Cysteine)FDA Link 02/2011 - 05/2010
2	ZincIBA 01/2008 - 02/2002
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2005 - 04/2003
1	CalciumIBA 01/2022
1	L-SelectinIBA 01/2019
1	LipopolysaccharidesIBA 01/2018
1	Raloxifene Hydrochloride (Evista)FDA Link 01/2018
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 01/2018
1	Selective Estrogen Receptor Modulators (SERM)IBA 01/2018
1	Suramin (Suramin Sodium)IBA 10/2017
1	Parathyroid Hormone (Parathormone)IBA 01/2017
1	IndicanIBA 01/2017
1	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2017
1	InterleukinsIBA 01/2017
1	4- (2- fluoro- 4- ((((2- phenylacetyl)amino)thioxomethyl)amino)phenoxy)- 7- methoxy- N- methyl- 6- quinolinecarboxamideIBA 09/2016
1	Tyrosine Kinase InhibitorsIBA 09/2016
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 09/2016
1	Proto-Oncogene Proteins c-metIBA 09/2016
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 09/2016
1	CryptoxanthinsIBA 01/2016
1	LuciferasesIBA 01/2016
1	Androgen Receptors (Androgen Receptor)IBA 01/2016
1	Prostaglandin-E SynthasesIBA 12/2015
1	Indicators and Reagents (Reagents)IBA 11/2015
1	Interleukin-1 (Interleukin 1)IBA 07/2015
1	Drug CarriersIBA 03/2015
1	Syndecan-4IBA 02/2015
1	Tissue Inhibitor of MetalloproteinasesIBA 01/2015
1	Polysaccharides (Glycans)IBA 10/2014
1	N- (2(R)- 2- (hydroxamidocarbonylmethyl)- 4- methylpentanoyl)- L- tryptophan methylamideIBA 03/2014
1	Matrix Metalloproteinase 12IBA 03/2014
1	ADAMTS5 ProteinIBA 04/2013
1	Leukocyte Elastase (Neutrophil Elastase)IBA 09/2012
1	Serine Proteases (Serine Protease)IBA 09/2012
1	AW 091IBA 02/2011
1	cathepsin SIBA 02/2011
1	PolymersIBA 02/2011
1	Collagen Type I (Type I Collagen)IBA 06/2010

Therapy/Procedure

7	Therapeutics 10/2017 - 02/2008
1	Oral Administration 09/2016